Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica

Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably play a pathogenic role. Here we show that a B-cell subpopulation, exhibiting the CD19(int)CD27(high)CD38(high)CD180(−) ph...

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Autors principals: Chihara, Norio, Aranami, Toshimasa, Sato, Wakiro, Miyazaki, Yusei, Miyake, Sachiko, Okamoto, Tomoko, Ogawa, Masafumi, Toda, Tatsushi, Yamamura, Takashi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048150/
https://ncbi.nlm.nih.gov/pubmed/21321193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017385108
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