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Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines
Smad3, a component of the TGFβ signaling pathway, contributes to G(1) arrest in breast cancer cells. Overexpression of the cell cycle mitogen, cyclin E, is associated with poor prognosis in breast cancer, and cyclin E/CDK2 mediated phosphorylation of Smad3 has been linked with inhibition of Smad3 ac...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047813/ https://ncbi.nlm.nih.gov/pubmed/21150326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.24.14158 |
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