The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein

A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes mellitus. This mutation is associated with severe peripheral T lymphopenia, as is mutation of the same gene in mice, but the mechanism by which GIMAP5 normally protects T c...

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Detalhes bibliográficos
Main Authors: Wong, Vivian WY, Saunders, Amy E, Hutchings, Amanda, Pascall, John C, Carter, Christine, Bright, Nicholas A, Walker, Simon A, Ktistakis, Nicholas T, Butcher, Geoffrey W
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047789/
https://ncbi.nlm.nih.gov/pubmed/21487483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/self.1.3.12819
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