APC/C(Cdc20) targets E2F1 for degradation in prometaphase

The mechanisms that control E2F-1 activity are complex. We previously showed that Chk1 and Chk2 are required for E2F1 stabilization and p73 target gene induction following DNA damage. To gain further insight into the processes regulating E2F1 protein stability, we focused our investigation on the me...

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Huvudupphovsmän: Peart, Melissa J, Poyurovsky, Masha V, Kass, Elizabeth M, Urist, Marshall, Verschuren, Emmy W, Summers, Matthew K, Jackson, Peter K, Prives, Carol
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2010
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Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047753/
https://ncbi.nlm.nih.gov/pubmed/20948288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.19.13162
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