Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain

BACKGROUND: RNA interference (RNAi) emerges as a powerful tool to induce loss-of-function phenotypes. In the context of the brain, gene manipulation is best targeted to specific subsets of cells in order to achieve a physiologically relevant outcome. Polymerase II-based viral expression systems can...

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Bibliographic Details
Main Authors: Liu, Beihui, Xu, Haibo, Paton, Julian FR, Kasparov, Sergey
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047298/
https://ncbi.nlm.nih.gov/pubmed/21134262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-93
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