Phase II Study of Imatinib Mesylate and Gemcitabine for First-line Treatment of Metastatic Pancreatic Cancer

BACKGROUND: Gemcitabine (GEM) is the standard of care for pancreatic cancer. Unfortunately, median progression-free survival (PFS) is 2.2 months and overall survival (OS) is 5.65 months. Imatinib mesylate (IM) inhibits the Bcr-Abl tyrosine kinase and receptors for platelet-derived growth factor (PDG...

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Main Authors: Moss, Rebecca A., Moore, Dirk, Mulchahy, Mary F., Nahum, Kenneth, Li, Hui, Moore, Katen, Fischer, Jane, Konduri, Srivani, Durivage, Henry, Poplin, Elizabeth
Format: Artigo
Sprog:Inglês
Udgivet: International Society of Gastrointestinal Oncology 2010
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047035/
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