Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1α Expression and Oxygen Metabolism

OBJECTIVE: Chronic hypoxia has been recognized as a key regulator in renal tubulointerstitial fibrosis, as seen in diabetic nephropathy, which is associated with the activation of hypoxia-inducible factor (HIF)-1α. We assess here the effects of the biguanide, metformin, on the expression of HIF-1α i...

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Main Authors: Takiyama, Yumi, Harumi, Tatsuo, Watanabe, Jun, Fujita, Yukihiro, Honjo, Jun, Shimizu, Norihiko, Makino, Yuichi, Haneda, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2011
Assuntos:
Complications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046859/
https://ncbi.nlm.nih.gov/pubmed/21282369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0655
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