RIG-I– and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates β-Cell Death in Fulminant Type 1 Diabetes

OBJECTIVE: The contribution of innate immunity responsible for aggressive β-cell destruction in human fulminant type 1 diabetes is unclear. RESEARCH DESIGN AND METHODS: Islet cell expression of Toll-like receptors (TLRs), cytoplasmic retinoic acid–inducible gene I (RIG-I)-like receptors, downstream...

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Päätekijät: Aida, Kaoru, Nishida, Yoriko, Tanaka, Shoichiro, Maruyama, Taro, Shimada, Akira, Awata, Takuya, Suzuki, Masako, Shimura, Hiroki, Takizawa, Soichi, Ichijo, Masashi, Akiyama, Daiichiro, Furuya, Fumihiko, Kawaguchi, Akio, Kaneshige, Masahiro, Itakura, Jun, Fujii, Hideki, Endo, Toyoshi, Kobayashi, Tetsuro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Diabetes Association 2011
Aiheet:
Immunology and Transplantation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046849/
https://ncbi.nlm.nih.gov/pubmed/21289206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0795
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