Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

OBJECTIVE: We have previously shown that serum insulin levels decrease threefold and blood glucose levels remain normal in mice fed a leucine-deficient diet, suggesting increased insulin sensitivity. The goal of the current study is to investigate this possibility and elucidate the underlying cellul...

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Autori principali: Xiao, Fei, Huang, Zhiying, Li, Houkai, Yu, Junjie, Wang, Chunxia, Chen, Shanghai, Meng, Qingshu, Cheng, Ying, Gao, Xiang, Li, Jia, Liu, Yong, Guo, Feifan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2011
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046835/
https://ncbi.nlm.nih.gov/pubmed/21282364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1246
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