Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

OBJECTIVE: AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons causes obesity and defective neuronal glucose sensing. LKB1, the Peutz-...

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Bibliografische gegevens
Hoofdauteurs: Claret, Marc, Smith, Mark A., Knauf, Claude, Al-Qassab, Hind, Woods, Angela, Heslegrave, Amanda, Piipari, Kaisa, Emmanuel, Julian J., Colom, André, Valet, Philippe, Cani, Patrice D., Begum, Ghazala, White, Anne, Mucket, Phillip, Peters, Marco, Mizuno, Keiko, Batterham, Rachel L., Giese, K. Peter, Ashworth, Alan, Burcelin, Remy, Ashford, Michael L., Carling, David, Withers, Dominic J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Diabetes Association 2011
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046834/
https://ncbi.nlm.nih.gov/pubmed/21266325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1055
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