The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals: Evidence for Interaction With Obesity in Diabetic Patients

OBJECTIVE: Insulin resistance (IR) and cardiovascular disease may share a common genetic background. We investigated the role of IR-associated ENPP1 K121Q polymorphism (rs1044498) on cardiovascular disease in high-risk individuals. RESEARCH DESIGN AND METHODS: A prospective study (average follow-up,...

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Autors principals: Bacci, Simonetta, Rizza, Stefano, Prudente, Sabrina, Spoto, Belinda, Powers, Christine, Facciorusso, Antonio, Pacilli, Antonio, Lauro, Davide, Testa, Alessandra, Zhang, Yuan-Yuan, Di Stolfo, Giuseppe, Mallamaci, Francesca, Tripepi, Giovanni, Xu, Rui, Mangiacotti, Davide, Aucella, Filippo, Lauro, Renato, Gervino, Ernest V., Hauser, Thomas H., Copetti, Massimiliano, De Cosmo, Salvatore, Pellegrini, Fabio, Zoccali, Carmine, Federici, Massimo, Doria, Alessandro, Trischitta, Vincenzo
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046818/
https://ncbi.nlm.nih.gov/pubmed/21282363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1300
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