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Superactive octapeptide somatostatin analogs containing tryptophan at position 1.

We synthesized a series of octapeptide analogs of somatostatin, containing N-terminal tryptophan or another amino acid followed by the hexapeptide sequences Cys-Phe-D-Trp-Lys-Thr-Cys or Cys-Tyr-D-Trp-Lys-Val-Cys and a C-terminal threoninamide or tryptophanamide. After purification by HPLC, the inhib...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cai, R Z, Karashima, T, Guoth, J, Szoke, B, Olsen, D, Schally, A V
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304680/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2882520/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2502
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