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Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway

The X-ray structure determination at 2.4 Å resolution of the putative orsellinic acid C3 O-methyltransferase (CalO1) involved in calicheamicin biosynthesis is reported. Comparison of CalO1 with a homology model of the functionally related calicheamicin orsellinic acid C2 O-methyltransferase (CalO6)...

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Detalhes bibliográficos
Main Authors: Chang, Aram, Singh, Shanteri, Bingman, Craig A., Thorson, Jon S., Phillips, George N.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046457/
https://ncbi.nlm.nih.gov/pubmed/21358050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744491100360X
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