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Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.

Addition of phorbol 12,13-dibutyrate (PBt2) in the presence of forskolin or cholera toxin caused marked (6- to 8-fold) and rapid accumulation of cAMP in Swiss 3T3 cells. The effect of PBt2 is mediated by protein kinase C because the synthetic diacylglycerol 1-oleoyl-2 acetylglycerol substitutes for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Rozengurt, E, Murray, M, Zachary, I, Collins, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304634/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3031676/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2282
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