Initiation of translation of the FMR1 mRNA occurs predominantly through 5′end-dependent ribosomal scanning

The fragile X mental retardation 1 (FMR1) gene contains a CGG repeat within its 5′ untranslated region (5′UTR) that, when expanded to 55–200 CGG repeats (premutation allele), can result in the late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome. The CGG-repeat is expec...

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Bibliografiske detaljer
Main Authors: Ludwig, Anna L, Hershey, John WB, Hagerman, Paul J
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046292/
https://ncbi.nlm.nih.gov/pubmed/21237174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.01.006
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