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Initiation of translation of the FMR1 mRNA occurs predominantly through 5′end-dependent ribosomal scanning
The fragile X mental retardation 1 (FMR1) gene contains a CGG repeat within its 5′ untranslated region (5′UTR) that, when expanded to 55–200 CGG repeats (premutation allele), can result in the late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome. The CGG-repeat is expec...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046292/ https://ncbi.nlm.nih.gov/pubmed/21237174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.01.006 |
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