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Induction of differentiation of human promyelocytic leukemia cell line HL-60 by retinoyl glucuronide, a biologically active metabolite of vitamin A.

We examined the differentiation activity of retinoyl beta-D-glucuronide, a biologically active physiological metabolite of vitamin A, using the human promyelocytic leukemic cell line HL-60, which can be induced to differentiate with retinoic acid. Retinoyl beta-D-glucuronide (1 microM) inhibited HL-...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Zile, M H, Cullum, M E, Simpson, R U, Barua, A B, Swartz, D A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304618/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3470785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.8.2208
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