Combination Treatment with TRA-8 Anti – Death Receptor 5 Antibody and CPT-11 Induces Tumor Regression in an Orthotopic Model of Pancreatic Cancer

PURPOSE: Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11). EXPERIMENTAL DESIGN: MIA PaCa-2 and S2VP10 cells were treated with TRA-8 and/or CPT 11. Cell viability was determin...

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Auteurs principaux: DeRosier, Leo Christopher, Buchsbaum, Donald J., Oliver, Patsy G., Huang, Zhi-Qiang, Sellers, Jeffrey C., Grizzle, William E., Wang, Wenquan, Zhou, Tong, Zinn, Kurt R., Long, Joshua W., Vickers, Selwyn M.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045836/
https://ncbi.nlm.nih.gov/pubmed/17875786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1075
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