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Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro.

We report that 2',3'-dideoxyadenosine and 2',3'-dideoxycytidine inhibit retroviral DNA synthesis and mRNA expression in T cells exposed to the virus that causes acquired immunodeficiency syndrome, and afford such cells long-term protection in vitro under conditions of substantial viral excess. Both...

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Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Mitsuya, H, Jarrett, R F, Matsukura, M, Di Marzo Veronese, F, DeVico, A L, Sarngadharan, M G, Johns, D G, Reitz, M S, Broder, S
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1987
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2436223/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.7.2033
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