A Novel Flexible Multiplex Bead-based Assay for Detecting Germline CDKN2A and CDK4 Variants in Melanoma-Prone Kindreds

BACKGROUND: The presence of recurrent high-risk mutations in CDKN2A and CDK4 among melanoma-prone kindreds suggests that a high-throughput, multiplex assay could serve as an effective initial screening tool. Moreover, with the emergence of new melanoma risk single nucleotide polymorphisms (SNPs) thr...

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Main Authors: Lang, Julie, Shennan, Michael, Njauw, Jenny Chi-Ni, Luo, Su, Bishop, Julia Newton, Harland, Mark, Hayward, Nicholas K., Tucker, Margaret A., Goldstein, Alisa M., Landi, Maria Teresa, Puig, Susana, Gruis, Nelleke A., Bergman, Wilma, Bianchi-Scarra, Giovanna, Ghiorzo, Paola, Hogg, David, Tsao, Hensin
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045700/
https://ncbi.nlm.nih.gov/pubmed/21085193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.331
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