Intergenotypic chimeric hepatitis E viruses (HEV) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs

Genotypes 1 and 2 hepatitis E virus (HEV) infect only humans whereas genotypes 3 and 4 HEV infect both humans and pigs. To evaluate the mechanism of cross-species HEV infection between humans and swine, in this study we constructed five intergenotypic chimeric viruses and tested for their infectivit...

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Bibliographic Details
Main Authors: Feagins, Alicia R., Córdoba, Laura, Sanford, Brent J., Dryman, Barbara A., Huang, Yao-Wei, LeRoith, Tanya, Emerson, Suzanne U., Meng, Xiang-Jin
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045649/
https://ncbi.nlm.nih.gov/pubmed/21195119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2010.12.011
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