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Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision
In fission yeast and other eukaryotes, Rec12 (Spo11) is thought to catalyze the formation of dsDNA breaks (DSBs) that initiate homologous recombination in meiosis. Rec12 is orthologous to the catalytic subunit of topoisomerase VI (Top6A). Guided by the crystal structure of Top6A, we engineered the r...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045620/ https://ncbi.nlm.nih.gov/pubmed/21030440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq993 |
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