Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

BACKGROUND: HIV-1 infected macrophages play an important role in rendering resting T cells permissive for infection, in spreading HIV-1 to T cells, and in the pathogenesis of AIDS dementia. During highly active anti-retroviral treatment (HAART), macrophages keep producing virus because tissue penetr...

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Main Authors: Bol, Sebastiaan M., Moerland, Perry D., Limou, Sophie, van Remmerden, Yvonne, Coulonges, Cédric, van Manen, Daniëlle, Herbeck, Joshua T., Fellay, Jacques, Sieberer, Margit, Sietzema, Jantine G., van 't Slot, Ruben, Martinson, Jeremy, Zagury, Jean-François, Schuitemaker, Hanneke, van 't Wout, Angélique B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045405/
https://ncbi.nlm.nih.gov/pubmed/21364930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017190
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