A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells

BACKGROUND: The protein kinase CK2 sustains multiple pro-survival functions in cellular DNA damage response and its level is tightly regulated in normal cells but elevated in cancers. Because CK2 is thus considered as potential therapeutic target, DNA double-strand break (DSB) formation and rejoinin...

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Autori principali: Zwicker, Felix, Ebert, Maren, Huber, Peter E, Debus, Jürgen, Weber, Klaus-Josef
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045342/
https://ncbi.nlm.nih.gov/pubmed/21310046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-6-15
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