A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells

BACKGROUND: The protein kinase CK2 sustains multiple pro-survival functions in cellular DNA damage response and its level is tightly regulated in normal cells but elevated in cancers. Because CK2 is thus considered as potential therapeutic target, DNA double-strand break (DSB) formation and rejoinin...

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Autors principals: Zwicker, Felix, Ebert, Maren, Huber, Peter E, Debus, Jürgen, Weber, Klaus-Josef
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045342/
https://ncbi.nlm.nih.gov/pubmed/21310046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-6-15
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