Isoflurane Depression of Spinal Nociceptive Processing and Minimum Alveolar Anesthetc Concentration are not Attenuated in Mice Expressing Isoflurane Resistant γ–Aminobutyric Acid-Type A Receptors

Anesthetics produce immobility and depress spinal nociceptive processing, but the exact sites and mechanisms of anesthetic action are unknown. The gamma-aminobutyric acid type-A (GABA(A)) receptor is thought to be important to anesthetic action. We studied knockin mice that had mutations in the alph...

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Main Authors: Kim, JongBun, Atherley, Richard, Werner, David F., Homanics, Gregg E., Carstens, Earl, Antognini, Joseph F.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045261/
https://ncbi.nlm.nih.gov/pubmed/17543455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2007.04.057
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