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Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

A high intrapulmonary protease burden is characteristic of cystic fibrosis (CF), and the resulting dysregulation of the protease/anti-protease balance has serious implications for inflammation in the CF lung. Because of this inflammation, micro-bleeds can occur releasing hemoglobin into the lung. Th...

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Detalhes bibliográficos
Main Authors: Cosgrove, Sonya, Chotirmall, Sanjay H., Greene, Catherine M., McElvaney, Noel G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045023/
https://ncbi.nlm.nih.gov/pubmed/21193404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183863
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