A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans Longevity

To investigate the biochemical mechanism underlying the effect of sterol deprivation on longevity in Caenorhabditis elegans, we treated parent worms (P0) with 25-azacoprostane (Aza), which inhibits sitosterol-to-cholesterol conversion, and measured mean lifespan (MLS) in F2 worms. At 25 μm (∼EC(50))...

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Bibliografiske detaljer
Main Authors: Cheong, Mi Cheong, Na, Keun, Kim, Heekyeong, Jeong, Seul-Ki, Joo, Hyoe-Jin, Chitwood, David J., Paik, Young-Ki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044981/
https://ncbi.nlm.nih.gov/pubmed/21186286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189183
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