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Serotonin (5-HT) Precursor Loading with 5-Hydroxy-L-tryptophan (5-HTP) Reduces Locomotor Activation Produced by (+)-Amphetamine in the Rat

BACKGROUND: Evidence suggests that increases in synaptic serotonin (5-HT) can reduce the stimulant properties of amphetamine-type drugs. Here we tested the hypothesis that administration of the 5-HT precursor 5-hydroxy-L-tryptophan (5-HTP), along with the peripheral decarboxylase inhibitor benserazi...

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Main Authors: Baumann, Michael H., Williams, Zakia, Zolkowska, Dorota, Rothman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044786/
https://ncbi.nlm.nih.gov/pubmed/21071157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2010.09.015
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