Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

BACKGROUND: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...

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Detalhes bibliográficos
Main Authors: Sharov, Alexei A, Nishiyama, Akira, Piao, Yulan, Correa-Cerro, Lina S, Amano, Tomokazu, Thomas, Marshall, Mehta, Samir, Ko, Minoru SH
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044670/
https://ncbi.nlm.nih.gov/pubmed/21306619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-102
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