Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site.

DBI (diazepam-binding inhibitor) is a putative neuromodulatory peptide isolated from rat brain that acts on gamma-aminobutyric acid-benzodiazepine-Cl- ionophore receptor complex inducing beta-carboline-like effects. We used a cDNA probe complementary to DBI mRNA and a specific antibody for rat DBI t...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Miyata, M, Mocchetti, I, Ferrarese, C, Guidotti, A, Costa, E
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304447/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3029781/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.5.1444
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