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Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory

The physiological role of vesicular zinc at central glutamatergic synapses remains poorly understood. Here we show that mice lacking the synapse-specific vesicular zinc transporter ZnT3 (ZnT3KO mice) have reduced activation of the Erk1/2 MAPK in hippocampal mossy fiber terminals, disinhibition of zi...

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Detalhes bibliográficos
Main Authors: Sindreu, Carlos, Palmiter, Richard D., Storm, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044399/
https://ncbi.nlm.nih.gov/pubmed/21245308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019166108
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