The choice of null distributions for detecting gene-gene interactions in genome-wide association studies

BACKGROUND: In genome-wide association studies (GWAS), the number of single-nucleotide polymorphisms (SNPs) typically ranges between 500,000 and 1,000,000. Accordingly, detecting gene-gene interactions in GWAS is computationally challenging because it involves hundreds of billions of SNP pairs. Stag...

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Bibliografiske detaljer
Main Authors: Yang, Can, Wan, Xiang, He, Zengyou, Yang, Qiang, Xue, Hong, Yu, Weichuan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044281/
https://ncbi.nlm.nih.gov/pubmed/21342556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-S1-S26
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