A Reversible Aptamer Improves Outcome and Safety in Murine Models of Stroke and Hemorrhage

Treatment of acute ischemic stroke with intravenous tissue-type plasminogen activator is underutilized partly due to the risk of life-threatening hemorrhage. In response to the clinical need for safer stroke therapy, we explored using an aptamer-based therapeutic strategy to promote cerebral reperfu...

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Bibliographic Details
Main Authors: Blake, Charlene M., Wang, Haichen, Laskowitz, Daniel T., Sullenger, Bruce A.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2011
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043993/
https://ncbi.nlm.nih.gov/pubmed/21142878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/oli.2010.0262
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