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Enzymatic Deamination of the Epigenetic Base N-6-Methyladenine

Two enzymes of unknown function from the amidohydrolase superfamily were discovered to catalyze the deamination of N-6-methyladenine to hypoxanthine and methyl amine. The methylation of adenine in bacterial DNA is a common modification for the protection of host DNA against restriction endonucleases...

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Bibliografiske detaljer
Main Authors: Kamat, Siddhesh S., Fan, Hao, Sauder, J. Michael, Burley, Stephen K., Shoichet, Brian K., Sali, Andrej, Raushel, Frank M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043370/
https://ncbi.nlm.nih.gov/pubmed/21275375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja110157u
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