The Pseudomonas aeruginosa Flagellum Confers Resistance to Pulmonary Surfactant Protein-A by Impacting the Production of Exoproteases Through Quorum-Sensing

Surfactant protein-A (SP-A) is an important antimicrobial protein that opsonizes and permeabilizes membranes of microbial pathogens in mammalian lungs. Previously, we have shown that Pseudomonas aeruginosa flagellum-deficient mutants are preferentially cleared in the lungs of wild-type mice by SP-A-...

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Main Authors: Kuang, Zhizhou, Hao, Yonghua, Hwang, Sunghei, Zhang, Shiping, Kim, Eunice, Akinbi, Henry T, Schurr, Michael J., Irvin, Randall T., Hassett, Daniel J, Lau, Gee W.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043146/
https://ncbi.nlm.nih.gov/pubmed/21205009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07516.x
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