The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

Darier's disease (DD) is an inherited autosomal-dominant skin disorder characterized histologically by loss of adhesion between keratinocytes. DD is typically caused by mutations in sarcoendoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), a major regulator of intracellular Ca(2+) homeostasi...

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Autors principals: Hobbs, Ryan P., Amargo, Evangeline V., Somasundaram, Agila, Simpson, Cory L., Prakriya, Murali, Denning, Mitchell F., Green, Kathleen J.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2011
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042836/
https://ncbi.nlm.nih.gov/pubmed/21156808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-163261
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