The Effects of pK(a) Tuning on the Thermodynamics and Kinetics of Folding: Design of a Solvent-Shielded Carboxylate Pair at the a-Position of a Coiled-Coil

The tuning of the pK(a) of ionizable residues plays a critical role in various protein functions, such as ligand-binding, catalysis, and allostery. Proteins harness the free energy of folding to position ionizable groups in highly specific environments that strongly affect their pK(a) values. To inv...

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Bibliographic Details
Main Authors: Lau, Wai Leung, DeGrado, William F., Roder, Heinrich
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042555/
https://ncbi.nlm.nih.gov/pubmed/20923665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.07.059
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