MEK2 Is Sufficient but Not Necessary for Proliferation and Anchorage-Independent Growth of SK-MEL-28 Melanoma Cells

Mitogen-activated protein kinase kinases (MKK or MEK) 1 and 2 are usually treated as redundant kinases. However, in assessing their relative contribution towards ERK-mediated biologic response investigators have relied on tests of necessity, not sufficiency. In response we developed a novel experime...

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Main Authors: Lee, Chih-Shia, Dykema, Karl J., Hawkins, Danielle M., Cherba, David M., Webb, Craig P., Furge, Kyle A., Duesbery, Nicholas S.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041822/
https://ncbi.nlm.nih.gov/pubmed/21365009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017165
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