Phenotype Sequencing: Identifying the Genes That Cause a Phenotype Directly from Pooled Sequencing of Independent Mutants

Random mutagenesis and phenotype screening provide a powerful method for dissecting microbial functions, but their results can be laborious to analyze experimentally. Each mutant strain may contain 50–100 random mutations, necessitating extensive functional experiments to determine which one causes...

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Detaylı Bibliyografya
Asıl Yazarlar: Harper, Marc A., Chen, Zugen, Toy, Traci, Machado, Iara M. P., Nelson, Stanley F., Liao, James C., Lee, Christopher J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041756/
https://ncbi.nlm.nih.gov/pubmed/21364744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016517
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