Drastically increased expression of MYC and FOS protooncogenes during in vitro differentiation of chronic lymphocytic leukemia cells.

Chronic lymphocytic leukemia cells, representing a clonal population of resting B lymphocytes, were induced to differentiate into immunoglobulin-secreting lymphoblasts and plasmablasts by phorbol 12-myristate 13-acetate. The induction resulted in a rapid increase in the molar ratio of secreted/membr...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Larsson, L G, Gray, H E, Tötterman, T, Pettersson, U, Nilsson, K
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304175/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3099293/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.1.223
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