Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [(18)F]-IL1RA and PET imaging in rats

BACKGROUND AND PURPOSE: Positron emission tomography (PET) has the potential to improve our understanding of the preclinical pharmacokinetics and metabolism of therapeutic agents, and is easily translated to clinical studies in humans. However, studies involving proteins radiolabelled with clinicall...

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Bibliografiske detaljer
Main Authors: Cawthorne, C, Prenant, C, Smigova, A, Julyan, P, Maroy, R, Herholz, K, Rothwell, N, Boutin, H
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041255/
https://ncbi.nlm.nih.gov/pubmed/20942812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01068.x
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