Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis

Interactions between RNA binding proteins (RBPs) and genes are not well understood, especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions of labile mRNAs, facilitating their translation into protein and has been hypothesized to be a tumor-maintenance gene. Elevated...

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Bibliographische Detailangaben
Hauptverfasser: Gubin, Matthew M, Calaluce, Robert, Davis, J Wade, Magee, Joseph D, Strouse, Connie S, Shaw, Daniel P, Ma, Lixin, Brown, Ashley, Hoffman, Timothy, Rold, Tammy L, Atasoy, Ulus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041167/
https://ncbi.nlm.nih.gov/pubmed/20724828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.16.12711
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