XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region

XMAP215/Dis1 family proteins positively regulate microtubule growth. Repeats at their N termini, called TOG domains, are important for this function. While TOG domains directly bind tubulin dimers, it is unclear how this interaction translates to polymerase activity. Understanding the functional rol...

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Detalles Bibliográficos
Main Authors: Widlund, Per O., Stear, Jeffrey H., Pozniakovsky, Andrei, Zanic, Marija, Reber, Simone, Brouhard, Gary J., Hyman, Anthony A., Howard, Jonathon
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041093/
https://ncbi.nlm.nih.gov/pubmed/21282620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016498108
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