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Ionizing radiation and hematopoietic malignancies: Altering the adaptive landscape

Somatic evolution, which underlies tumor progression, is driven by two essential components: (1) diversification of phenotypes through heritable mutations and epigenetic changes and (2) selection for mutant clones which possess higher fitness. Exposure to ionizing radiation (IR) is highly associated...

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Autors principals: Fleenor, Courtney J, Marusyk, Andriy, DeGregori, James
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040925/
https://ncbi.nlm.nih.gov/pubmed/20676038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.15.12311
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