A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.

A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein and a 22-kD polypeptide, is a critical component of the phagocyte NADPH-oxidase responsible for the generation of superoxide anion. Mutations in the gene for the 91-kD chain of this cytochrome result in the X-linked form of...

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Pubblicato in:	J Clin Invest
Autori principali:	Dinauer, M C, Curnutte, J T, Rosen, H, Orkin, S H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114393
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