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Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

Checkpoint kinase 2 (CHK2) is a major effector of the DNA damage response pathway and although its mechanism of activation has been well studied, the attenuation of its activity following DNA damage has not been explored. Here, we identify the B’α subunit of protein phosphatase 2A (PP2A) as a CHK2 b...

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Detalhes bibliográficos
Main Authors: Freeman, Alyson K., Dapic, Virna, Monteiro, Alvaro N.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040716/
https://ncbi.nlm.nih.gov/pubmed/20160490
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