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Low Viscosity Highly Concentrated Injectable Nonaqueous Suspensions of Lysozyme Microparticles

Subcutaneous injection of concentrated protein and peptide solutions, in the range of 100–400 mg/mL, is often not possible with a 25- to 27-gauge needle, as the viscosity can be well above 50 cP. Apparent viscosities below this limit are reported for suspensions of milled lysozyme microparticles up...

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Detalhes bibliográficos
Main Authors: Miller, Maria A., Engstrom, Joshua D., Ludher, Baltej S., Johnston, Keith P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040681/
https://ncbi.nlm.nih.gov/pubmed/19803503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la9023426
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