Human mannose-binding protein activates the alternative complement pathway and enhances serum bactericidal activity on a mannose-rich isolate of Salmonella.

The human mannose-binding protein (MBP) is a multimeric serum protein that is divided into three domains, a cysteine-rich NH2-terminal domain that stabilizes the collagen alpha helix of the second domain and a third COOH-terminal carbohydrate recognition domain. Previous studies have shown that both...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Schweinle, J E, Ezekowitz, R A, Tenner, A J, Kuhlman, M, Joiner, K A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2592561/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114367
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