Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.

AA is metabolized by a cytochrome P450, NADPH-dependent epoxygenase to four regioisomeric epoxyeicosatrienoic acids (EETs). The EETs are further hydrated enzymatically to their respective diols, vic-dihydroxyeicosatrienoic acids (DHETs). We studied the effect of pretreatment with DHETs on 10 microU/...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Hirt, D L, Capdevila, J, Falck, J R, Breyer, M D, Jacobson, H R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114365
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