Selective ERK Activation Differentiates Mouse and Human Tolerogenic Dendritic Cells, Expands Antigen-Specific Regulatory T Cells, and Suppresses Experimental Inflammatory Arthritis

OBJECTIVE: Most therapeutic treatments for autoimmune arthritis rely on immunosuppressive drugs, which have side effects. Although a previous study by our group showed that specific ERK activation suppressed immune responses, its application in a therapeutic setting has never been tested. The aim of...

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Main Authors: Arce, Frederick, Breckpot, Karine, Stephenson, Holly, Karwacz, Katarzyna, Ehrenstein, Michael R, Collins, Mary, Escors, David
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2011
Teme:
Experimental Arthritis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040564/
https://ncbi.nlm.nih.gov/pubmed/20967853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30099
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